尹瑞娟

海洋生物碱杂多环的合成及其结构优化与构效关系研究

现任青岛海洋生物医药研究院现代海洋药物研发室研发工程师，兼任中国海洋大学校外合作导师，作为研发骨干，主要从事海洋生物碱杂多环的合成及其结构优化与构效关系的研究工作。

1. Yue Zhang#, Ruijuan Yin#, Hao Jiang#, Chaoming Wang, Xiao Wang, Dongping Wang, Kai Zhang, Rilei Yu*, Xuechen Li*, Tao Jiang*. Peptide stapling through site-directed conjugation of triazine moieties to the tyrosine residues of a peptide. Org. Lett. 2023, 25, 2248−2252.

2. Guorui Zhang#, Ruijuan Yin#, Xiufei Dai#, Guanzhao Wu; Xi Qi; Rilei Yu; Jing Li**, Tao Jiang*. Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxycamptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo. Eur. J. Med. Chem. 2022, 241, 114610.

3. Kai Zhang#, Xian Guan#, Xiao Zhang, Lu Liu, Ruijuan Yin*, Tao Jiang*. Protective effects of marine alkaloid neolamellarin A derivatives against glutamate induced PC12 cell apoptosis, Mar. Drugs, 2022, 20, 262.

4. Yixuan Zhang, Ruijuan Yin, Guanzhao Wu, Mingming Yu, Jiannan Liu, Xueting Wang, Xuemeng Liu, Huashi Guan, Rilei Yu**, Tao Jiang*. Self-assembling nanoparticles of dually hydrophobic prodrugs constructed from camptothecin analogue for cancer therapy. Eur. J. Med. Chem. 2020, 200, 112365-112376.

5. Wei Wang#, Ruijuan Yin#, Meng Zhang#, Rilei Yu, Cui Hao, Lijuan Zhang*, Tao Jiang*. Boronic acid modifications enhance the anti-influenza A virus activities of novel quindoline derivatives. J. Med. Chem. 2017, 60, 2840-2852.

6. Long Jiang, Ruijuan Yin, Xueting Wang, Jiajia Dai, Jing Li, Tao Jiang*, Rilei Yu**. Design and synthesis of neolamellarin a derivatives targeting heat shock protein 90. Eur. J. Med. Chem. 2017, 135: 24-33.

7. Ruijuan Yin#, Meng Zhang#, Cui Hao#, Wei Wang, Peiju Qiu, Shengbiao Wan, Lijuan Zhang*, Tao Jiang*. Different cytotoxicities and cellular localizations of novel quindoline derivatives with or without boronic acid modifications in cancer cells. Chem. Commun. 2013, 49, 8516.

8. Bin Wei#, Na Weng#, Lei Fu, Yuxuan Li, Xu Wang*, Ruijuan Yin*, Tao Jiang. Synthesis and bioactivity evaluation of a myelin-specific contrast agent for magnetic resonance imaging of myelination in central nervous system. Bioorg. Med. Chem. 2023, 84, 117257.

9. Xiufen Dai#, Guanzhao Wu#, Yixuan Zhang, Xiaomin Zhang, Ruijuan Yin, Xin Qi*, Jing Li*, Tao Jiang. Design, synthesis, and in vitro/in vivo anti-cancer activities of novel (20S)-10,11-methylenedioxycamptothecin heterocyclic derivatives. Int. J. Mol. Sci. 2020, 21, 8495.

10. Hongfei Jiang, Xueyang Dong, Xin Jin, Danyang Zhu, Ruijuan Yin, Rilei Yu, Shengbiao Wan, Lijuan Zhang, Tao Jiang*. Efficient synthesis of five types of heterocyclic compounds via intramolecular elimination using ultrasound-static heating technique. Chem. Asian J. 2018, 13, 2009-2013.

1.江涛; 张海霖; 尹瑞娟; 钟腾江; 刘璐; 董雪洋; 吲哚嘧啶类海洋生物碱Meridianin G衍生物及其制备方法和应用, 2019-7-23, 中国, ZL201611143333.5.

2.江涛; 董雪洋; 张丽娟; 仝升; 尹瑞娟; 张海霖; 嘧啶基吲哚衍生物及其制备方法和在制备抗肿瘤药物中的应用, 2019-7-23, 中国, ZL201611143338.8.

3.江涛; 尹瑞娟; 张丽娟; 吲哚并喹啉衍生物及其制备方法和应用, 2016-7-20, 中国, ZL201310481986.4.

4.江涛; 尹瑞娟; 姜龙; 张丽娟; 吡咯类海洋生物碱Neolamellarin A类似物及其制备方法和应用, 2014-1-24, 中国, ZL201410044120.1.

1.国家自然科学基金，82003583，2021-2023，在研，主持。

2.国家自然科学基金，82073759，2021-2024，在研，参与。

3.国家自然科学基金，81874320，2019-2022，结题，参与。

4.国家自然科学基金联合基金项目，U1706213，2018-2021，结题，参与。

5.粤港澳大湾区精准医学研究院（广州）合作研究项目，IPM2021C009，2022-2024，在研，参与。

6.山东省重大科技创新工程专项，2018SDKJ0403，结题，参与。

7.山东省自然科学基金，ZR2018BH039，2018-2020，结题，主持。