张家祥

1. 1.    以高分子材料为核心的新型药物载体以及药物递送体系研究

2. 2.    以热熔挤出技术为核心的新型药物递送技术研究

3. 3.    以增材制造技术为核心的药物制剂技术研究

4. 4.    固体分散体，药物共晶以及缓控释制剂的研究与开发

5. 
   

主要从事物理药剂学、工业药剂学以及制药工程领域的研究，研究方向包括药物递释、口服缓控释制剂研发和热熔挤出、3D 打印技术应用等。曾主持美国FDA 关键路线研究课题1项，完成UT Austin与Advance Materials企业合作项目1项，构建了连续热熔挤出固体分散体/药物共晶技术，解决了苯妥英、吲哚美辛等BCS-II 类或IV 类药物溶出度低以及产率低等关键技术难题。构建了基于3D 打印的制剂成型技术，实现溶出动力学的精准调控，满足患者对药物制剂个体化需求；构建了一套业内领先的热熔挤出-3D 打印联用的药物制剂平台，推动了制药领域由药企主导的工业化生产到以病患为中心的需求引领模式的转变。近5 年内在本领域内核心期刊发表SCI 论文21篇，其中高被引文章2篇，累计引用960 余次，单篇最高被引300余次；多次获国际学术会议最佳演讲、最佳摘要及年会奖励基金等奖励；获6 项中国、4项国际专利授权。

International Journal of Pharmaceutics，Carbon hydrate Polymers，AAPS PharmSciTech，Journal of Drug  Delivery Science and Technology，Pharmaceutics审稿人

以病患为中心的个体化药物药物制剂研发

1. 1.    Zhang, J.; Thakkar, R.; Kulkarni, V.R.; Zhang, Y.; Lu, A.; Maniruzzaman, M. Investigation of the Fused Deposition Modeling Additive Manufacturing I: Influence of Process Temperature on the Quality and Crystallinity of the Dosage Forms. AAPS PharmSciTech2021, 22, 1–14, doi:10.1208/s12249-021-02094-8.

2. 2.    Zhang, J.; Lu, A.; Thakkar, R.; Zhang, Y.; Maniruzzaman, M. Development and Evaluation of Amorphous Oral Thin Films Using Solvent-Free Processes: Comparison between 3D Printing and Hot-Melt Extrusion Technologies. Pharm. 2021, Vol. 13, Page 1613 2021, 13, 1613, doi:10.3390/PHARMACEUTICS13101613.
   

3. 3.    Zhang, J.; Thakkar, R.; Zhang, Y.; Maniruzzaman, M. Structure-Function Correlation and Personalized 3D Printed Tablets Using a Quality by Design (QbD) Approach. Int. J. Pharm. 2020, 590, 378–5173, doi:10.1016/j.ijpharm.2020.119945.
   

4. 4.    Zhang, J.; Thakkar, R.; Zhang, Y.; Maniruzzaman, M. Microwave Induced Dielectric Heating for the On-Demand Development of Indomethacin Amorphous Solid Dispersion Tablets. J. Drug Deliv. Sci. Technol. 2020, 102109, doi:10.1016/j.jddst.2020.102109.
   

5. 5.    Zhang, J.; Xu, P.; Vo, A.Q.; Repka, M.A. Oral Drug Delivery Systems Using Core–Shell Structure Additive Manufacturing Technologies: A Proof-of-Concept Study. J. Pharm. Pharmacol. 2021, XX, 1–9, doi:10.1093/jpp/rgaa037.
   

6. 6.    Zhang, J.; Xu, P.; Vo, A.Q.; Bandari, S.; Yang, F.; Durig, T.; Repka, M.A. Development and Evaluation of Pharmaceutical 3D Printability for Hot Melt Extruded Cellulose-Based Filaments. J. Drug Deliv. Sci. Technol. 2019, 52, 292–302, doi:10.1016/j.jddst.2019.04.043.
   

7. 7.    Zhang J, Vo AQ, Feng X, Bandari S, Repka MA. Pharmaceutical Additive Manufacturing: a Novel Tool for Complex and Personalized Drug Delivery Systems. AAPS PharmSciTech.
   

8. 8.    Zhang J, Feng X, Patil H, Tiwari R V., Repka MA. Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets. Int. J. Pharm. 2017;519:186–97. (高被引)
   

9. 9.    Zhang J, Yang W, Vo AQ, Feng X, Ye X, Kim DW, Repka MA. Hydroxypropyl methylcellulose-based controlled release dosage by melt extrusion and 3D printing: Structure and drug release correlation. Carbohydr. Polym. 2017;177:49– 57,doi:10.1016/j.carbpol.2017.08.058
   

10. 10.    Öblom H, Zhang J, Pimparade M, Speer I, Preis M, Repka, M, Sandler N., 3D-printed isoniazid tablets for the treatment and prevention of tuberculosis — Personalized dosing and drug release., AAPS PharmSciTech., 2019 (高被引)

1. 1.    张家祥;杨微微；一种具有在线检测功能的制药设备CN109498455A

2. 2.    张家祥; 杨微微；一种可伸缩的多段式3D打印人工肋骨CN201811133849

3. 3.    Mohammed Maniruzzaman, Jiaxiang Zhang, Composition and Cocrystals using Dielectric Heating with Dispersive and Distributive Mixing, PCT/US2021/062768

4. 4.    Mohammed Maniruzzaman, Jiaxiang Zhang, Rishi Thakkar, Pharmaceutical Composition Containing Cocrystals for Additive Manufacturing, PCT/US2021/046047

5. 5.    Mohammed Maniruzzaman, Jiaxiang Zhang, Rishi Thakkar, Methods of Producing Pharmaceutical Cocrystals for Additive Manufacturing, PCT/US2021/046048

6. 6.    Mohammed Maniruzzaman, Jiaxiang Zhang, Rishi Thakkar, Granulesfor 3D Printing Technology, PCT/US2021/032881

7. 7.    张宇峰，张家祥，黄淑真；一种3D打印送料机构快换结构CN207808507U

8. 8.    张宇峰，张家祥，黄淑真；一种3D打印的打印喷嘴冷却系统CN207649193U

9. 9.    张宇峰，张家祥，黄淑真；一种3D打印送料机构CN207808484U

10. 10.  张宇峰，张家祥，黄淑真；一种3D打印的底板加热系统CN207643726U

1. 1.    中国海洋大学“蓝药人才”工程，蓝药项目主研，2022-2027，在研，主持

2. 2.    泰山学者青年专家项目，2022-2025，在研，主持