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首页 > Talent team > Scientist > 现代海洋药物研发室 > 秦冲

秦冲

秦冲 中国海洋大学医药学院教授、博士生导师
Employer:

现代海洋药物研发室

Research Direction:
  1. 1.    基于靶向蛋白降解(PROTACs)策略的小分子先导化合物发现和新药发现

  2. 2.    去势抵抗性前列腺癌治疗药物研究

  3. 3.    海洋天然活性物质的结构多样性修饰及成药性优化


秦冲课题组主页


Intro:

教授,博士生导师,青岛海洋生物医药研究院副院长。主持国家高层次青年人才项目(2021)、国家重点研发计划青年科学家项目(2022)、国家自然基金青年基金(2021)、山东省“泰山学者”青年专家(2020)、山东省自然基金优秀青年基金(2021)等研究项目,获北京市自然科学奖一等奖(2019)。近年来在 J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、J. Med. Chem. 等杂志发表学术论文二十余篇。


Adjunct Research Positions:

担任J. Med. Chem.等国际期刊审稿人。


Exchange:

北京市自然科学奖一等奖(2019)

主讲《高等药物化学》研究生课程获教育部“拓金计划”示范课程(2022)、山东省研究生教育优质课程(2021)

北京大学学生五四奖章(2014)


Publications:
  1. 1.    Siqi Zhang+, Xiaolei Meng+, Sai Zhang+, Baohu Li, WencongJin, Chengwei Zhang, Zhaojuan Liu, Xiaolin Hu, Ling Ge, Zhonghao Yu, Zhuoyue Li, Shumin Ma, Xiao Wang, Liming Li, Chong Qin*. Design, Synthesis and Biological Evaluation of Androgen Receptor (AR) Antagonist-Heat Shock Protein 90 (Hsp90) Inhibitor Conjugates for Targeted Therapy of Castration-Resistant Prostate Cancer. J. Med. Chem.2023, doi: 10.1021/acs.jmedchem.2c01970. (IF: 8.039)

  2. 2.    Liming Li+*, Heping Zheng+, Xuepei Ma, Jie Bai, Shumin Ma, Zhuoyue Li, Chong Qin*. Inhibition of Astrocytic Carbohydrate Sulfotransferase 15 Promotes Nerve Repair After Spinal Cord Injury via Mitigation of CSPG Mediated Axonal Inhibition. Cell. Mol. Neurobiol.2023, doi: 10.1007/s10571-023-01333-9. (IF: 4.231)

  3. 3.   Qiang Wang, Baohu Li, Wenkai Zhang, Zhuoyue Li, Bo Jiang*, Sichuan Hou*, Shumin Ma*, Chong Qin*, Lethal Activity of BRD4 PROTAC Degrader QCA570 Against Bladder Cancer Cells. Front. Chem.2023, doi.org/10.3389/fchem.2023.1121724. (IF: 5.545)

  4. 4.    Ruxuan Wang, Tengjiang Zhong, QiongBian, Sai Zhang, Xiaolu Ma, Liming Li, Yihua Xu, Yueting Gu, Anran Yuan, Weitong Hu, Chong Qin*,Jianqing Gao*, PROTAC Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration. Small Methods. 2023, 7, 2201293. (IF: 14.188)

  5. 5.    Chong Qin and Ning Jiao*, Iron-Facilitated Direct Oxidative C−H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles. J. Am. Chem. Soc.2010, 132, 15893-15895;

  6. 6.    Chong Qin, Wang Zhou, Feng Chen, Yang Ou and Ning Jiao*, Iron-catalyzed C-H and C-C Bond Cleavage: A Direct Approach to Amides from Simple Hydrocarbon Molecules, Angew. Chem. Int. Ed. 2011, 50, 12595-12599;

  7. 7.    Chong Qin, Tao Shen, Conghui Tang and Ning Jiao*, FeCl2-promoted Unactivated C-C Bond Cleavage of Alkylarenes and Polystyrene: Direct Synthesis of Versatile Arylamines, Angew. Chem. Int. Ed.2012, 51, 6971-6975;

  8. 8.    Chong Qin, Peng Feng, Yang Ou, Tao Shen, Teng Wang and Ning Jiao*, Highly Selective Csp2-Csp Bond Cleavage: The Nitrogenation of Alkynes to Amides.Angew. Chem. Int. Ed. 2013, 52, 7850-7854;

  9. 9.    Chong Qin,+YijinSu,+Xiaodong Shi and Ning Jiao*, Splitting a Substrate into Three Parts: Gold-Catalyzed Nitrogenation of Alkynes by C-C and C≡C Bond Cleavage. Angew. Chem. Int. Ed. 2016, 55, 350-354;

  10. 10.   Chong Qin,+Yang Hu,+ Bing Zhou,+... Shaomeng Wang*, Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J. Med. Chem.2018, 61, 6685–6704.



Project:
  1. 1.    国家高层次青年人才项目,300万,2022.1-2024.12,主持;

  2. 2.    国家重点研发计划青年科学家项目(2022YFC2804400),200万,2022.11-2025.10,主持;

  3. 3.    国家自然科学基金青年基金(22107095),30万,2022.1-2024.12,主持;

  4. 4.    山东省“泰山学者”青年专家(tsqn201909171),100万,2020.01-2024.12,主持;

  5. 5.    山东省自然科学基金优秀青年基金(22107095),40万,2022.1-2024.12,主持。


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